Devon Island Programs, 1966

Five field parties availed themselves of the facilities at the Arctic Institute's Base Camp on Devon Island during the 1966 field season. Each party consisted of two men (or in the case of the glaciology party, one man and one woman). The general areas of study were glaciology, botany, ornithology, periglacial geomorphology, and glacioisostatic geomorphology. A base-camp staff of three, including two Boy Scouts, provided a valuable service in maintaining the Base Camp, and in assisting the various field parties as required. The first party flew to Devon Island from Resolute Bay on 11 June, and the remainder followed on 16 and 29 June. Some of the party left Devon Island by air on 13 August, while the remainder were evacuated by the icebreaker John A. Macdonald on 29 August. Transport to and from Devon Island was greatly simplified through the kind assistance of Dr. F. Roots of the Polar Continental Shelf Project; whenever weather and the needs of his own project permitted, he made every effort to assist in the movement of equipment and personnel to and from Devon Island. ..

Pediatric Transplantation in the United States, 1996–2005

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73448/1/j.1600-6143.2007.01780.x.pd

Applied Solutions for Water Resource Challenges: Floods, Contamination and Upland Water Storage

poster abstractThe Center for Earth and Environmental Science, an IUPUI Signature Center, is working on a series of water resources problems and creating solutions. A series of collaborative projects are underway with the HUD, FEMA, the Office of Community and Rural Affairs, the United States Geological Survey, the Indiana State Department of Agriculture, and an international corporate partner in Berlin, KompetenzZentrum Wasser Berlin. Flood Erosion Hazard Program CEES, the USGS, and Polis are working with HUD and the Office of Community and Rural Affairs, though the Indiana Silver Jackets, to create tools for the State of Indiana to incorporate flood erosion hazard risk assessments into community planning. Flooding remains the most costly natural hazard in the US and Indiana. Flood losses continue to rise despite billions of dollars in mitigation. The causes are complex and related to land use, infrastructure design and climate change. Following the June 2008 floods in Indiana, 39 counties were listed as Federal disaster areas. In early 2005, 90% of Indiana counties were declared federal disaster areas after heavy rains fell on saturated soil. There have been seven major regional flooding events since the “Great flood of 1913”. The frequency of large floods appears to be increasing. Four of the eight major floods have occurred since 1982 and the last two occurred in 2005 and 2008. From 1998 through 2007, total insured flood losses in Indiana exceeded $39.8 million. While more restricted in area than the floods of 2008; record flooding occurred again throughout central and southern Indiana in early 2011 following heavy rains in February and March. Traditional flood protection usually consists of three components: flood control reservoirs, urban levees/floodwalls, and agricultural levees. These traditional flood protection methods are focused on one aspect of flooding – inundation. However, the largest single source of flood losses, both in terms of cost and number of affected persons, is damage to transportation infrastructure. Fluvial erosion is a principal cause of this damage. This significant flood-related natural hazard – the “fluvial erosion hazard” (FEH) – is not a specific component of State and local mitigation programs. This project aims to generate the tools for inclusion of FEH into statewide and local community planning. Aquisafe II - Performance Analysis of Selected Mitigation Systems Used to Attenuate Non-Point Source Agricultural Pollution Aquisafe is an international research collaboration with Veolia Environment based in Paris, their corporate partner in Berlin (KompetenzZentrum Wasser – Berlin Center of Competence for Water), the German Federal Environmental Agency, German university partners, and French quasi-governmental agencies in Brittany, France. The project goals are to create new mitigation systems to capture and treat polluted agricultural water running off farm fields prior to flowing into area streams, especially those used for drinking water supplies. The contaminants of specific concern are nutrients (nitrogen and phosphorus) and pesticides (atrazine – a corn-herbicide with potential endocrine disrupting effects). We are testing 2-stage, constructed wetlands in Indianapolis, Indiana and Brittany, France that have been designed to intercept and convert contaminants to harmless compounds. Site designs are guided by laboratory technical scale experiments conducted in Berlin that identified the hydrologic retention times and suitable sources of organic carbon necessary for mitigating contaminants. Construction of the experimental systems will begin in April in the Eagle Creek Watershed in cooperation with a private farmer with initial results expected this summer

NucliTrack: An integrated nuclei tracking application

Summary: Live imaging studies give unparalleled insight into dynamic single cell behaviours and fate decisions. However, the challenge of reliably tracking single cells over long periods of time limits both the throughput and ease with which such studies can be performed. Here, we present NucliTrack, a cross platform solution for automatically segmenting, tracking and extracting features from fluorescently-labelled nuclei. NucliTrack performs similarly to other state-of-the-art cell tracking algorithms, but NucliTrack's interactive, graphical interface makes it significantly more user friendly. Availability: NucliTrack is available as a free, cross platform application, and open source Python package. Installation details and documentation are at: http://nuclitrack.readthedocs.io/en/latest / A video guide can be viewed online: https://www.youtube.com/watch?v=J6e0D9F-qSU Source code is available through Github: https://github.com/samocooper/nuclitrack . A Matlab toolbox is also available at: https://uk.mathworks.com/matlabcentral/fileexchange/61479-samocooper-nuclitrack-matlab. Contact: [email protected]. Supplementary information: Supplementary data are available at Bioinformatics online

Classification of phase transitions and ensemble inequivalence, in systems with long range interactions

Systems with long range interactions in general are not additive, which can lead to an inequivalence of the microcanonical and canonical ensembles. The microcanonical ensemble may show richer behavior than the canonical one, including negative specific heats and other non-common behaviors. We propose a classification of microcanonical phase transitions, of their link to canonical ones, and of the possible situations of ensemble inequivalence. We discuss previously observed phase transitions and inequivalence in self-gravitating, two-dimensional fluid dynamics and non-neutral plasmas. We note a number of generic situations that have not yet been observed in such systems.Comment: 42 pages, 11 figures. Accepted in Journal of Statistical Physics. Final versio

Late-Holocene floodplain development, land-use, and hydroclimate–flood relationships on the lower Ohio River, US

Floodplain development, land-use, and flooding on the lower Ohio River are investigated with a 3100-year-long sediment archive from Avery Lake, a swale lake on the Black Bottom floodplain in southern Illinois, US. In all, 12 radiocarbon dates show that Avery Lake formed at 1130 BCE (3100 cal. yr BP), almost 3000 years later than previously thought, indicating that the Black Bottom floodplain is younger and more dynamic than previously estimated. Three subsequent periods of extensive land clearance were identified by changes in pollen composition, corresponding to Native American occupations before 1500 CE and the current Euro-American occupation beginning in the 18th century. Sedimentation rates prior to 1820 CE changed independently of land clearance events, suggesting natural as opposed to land-use controls. Comparison with high-resolution paleoclimate data from Martin Lake, IN, indicates that lower Ohio River flooding was frequent when cold-season precipitation originating from the Pacific/Arctic predominated when atmospheric circulation resembled positive Pacific North American (PNA) conditions and the Pacific Decadal Oscillation (PDO) was in a positive mean state (1130 BCE to 350 CE and 1150–1820 CE). Conversely, Ohio River flooding was less frequent when warm-season precipitation from the Gulf of Mexico prevailed during negative PDO- and PNA-like mean states (350 and 1150 CE). This flood dynamic appears to have been fundamentally altered after 1820 CE. We suggest that extensive land clearance in the Ohio River watershed increased runoff and landscape erosion by reducing interception, infiltration, and evapotranspiration, thereby increasing flooding despite a shift to negative PDO- and PNA-like mean states. Predicted increases in average precipitation and extreme rainfall events across the mid-continental US are likely to perpetuate current trends toward more frequent flood events, because anthropogenic modifications have made the landscape less resilient to changing hydroclimatic conditions

Hydroxypyridinone and 5-Aminolaevulinic Acid Conjugates for Photodynamic Therapy

Photodynamic therapy (PDT) is a promising treatment strategy for malignant and nonmalignant lesions. 5-Aminolaevulinic acid (ALA) is used as a precursor of the photosensitizer, protoporphyrin IX (PpIX), in dermatology and urology. However, the effectiveness of ALA–PDT is limited by the relatively poor bioavailability of ALA and rapid conversion of PpIX to haem. The main goal of this study was to prepare and investigate a library of single conjugates designed to coadminister the bioactive agents ALA and hydroxypyridinone (HPO) iron chelators. A significant increase in intracellular PpIX levels was observed in all cell lines tested when compared to the administration of ALA alone. The higher PpIX levels observed using the conjugates correlated well with the observed phototoxicity following exposure of cells to light. Passive diffusion appears to be the main mechanism for the majority of ALA–HPOs investigated. This study demonstrates that ALA–HPOs significantly enhance phototherapeutic metabolite formation and phototoxicity